In Buenos Aires, a club resembling the Sydney Opera House is the place to be. Opera Bay has a large terrace overlooking a river with plenty of room for people to hang out and enjoy the view. Grab your dancing shoes, as there are three dance floors, each one with its own bar, pumping out house, hip-hop and other tunes. Wednesday is the best night to go. The party cranks up at 6 p.m.

For a more low-key spot, try Cafe Misterio in Montevideo's upscale Carrasco neighborhood. Founded by Roberto Behrens, famed conductor and boyfriend to Argentine actress Susana Jimenez, this 22-year-old hangout is great for blues lovers. It's great for seafood as well. Sushi and fish are popular items here. Don't forget to stroll through the historic streets when the night winds down.

On the other side of the Andes, the Aura club in Santiago blends eastern and western cultures into a high-end party hot spot. Feel the groove to lounge and house music. You can also take in jazz in this fiber-modern club. Sip on a drink and act sophisticated with no pretense.

Since 1995, Coyote Night & Fun has been Asuncion's premier place to party. This club has seen it all: fashion shows, concerts and parties with Paraguayan and international VIPs. Two dance floors pump hip-hop and alternative rhythms.

It's no secret that Rio de Janeiro is a partygoer's Mecca. Only five years old, Nuth Lounge is a bit of a local legend. Exotic, tropical decor mixes sophistication with a touch of nature at any of the three bars here. Grab a bite in the restaurant or just relax in the lounge in a large recliner. Nuth Lounge is the perfect place to chill.

Since 2000, Sao Paulo's Azucar night-club has been the place to be seen for the city's upwardly mobile professionals. As the name suggests, it's a Caribbean hangout. Get ready to dance salsa after some fine Cuban cuisine. Covering 250 square meters of the Itaim Bibi neighborhood, Azucar is right in the heart where Sao Paulo goes to party.

No trip to Mexico City is complete without a visit to The Whiskey, in the Hotel W. Choose from one of four venues inside. Pull up a chair in The Living Room, a soft, white room that's perfect for the urban minimalist. For a cozier affair, grab a drink in The Red Lounge, a smaller nook and a little more sinful. If that's too urban, relax in the Cocoa Bar. It's laid-back atmosphere is perfect for couples. Need some air? Just head for the balcony. It's big enough for 200 people. There are plenty of DJs on hand from Wednesday through Saturday spinning lounge music until late into the night.

In Guadalajara, Simone keeps the hip in Mexico's second-largest city coming back for more. Popular among the business crowd, the nightclub is perched over a restaurant with a curious name: Nude. Photos of a naked Mexican artist cover the walls. Just two blocks off the Avenida Chapultepec, in the city's famous Zona Rosa district, Simond is as chic as it gets. It's also as modern as it gets. Tubes run from the ground to the ceiling to give it a futuristic effect. Simond is brought to you by the same people who own Santo Coyote, a popular restaurant in Guadalajara.

Arguably one of the best restaurants in Monterrey, Senor Tanaka serves up Japanese and South American cuisine. Not hungry? Grab a drink. Many come here just for the atmosphere. And safety too. Security guards patrol a large, private parking lot.

Everybody knows Colombia and Venezuela are famous for their music and beautiful women. Why not visit both places and compare? Bogota's Andres Came de Res draws in high-rolling locals and tourists alike for Colombian cuisine. Andres, as it's known locally, is a festive place. It's very colorful, too. Drawings of saintly figures and graffiti cover the wails in this rustic hangout. Getting there is kind of a haul, though. It's in Chia, a community 40 minutes outside of Bogota.

In Caracas, Malabar is a must when the workday ends, especially if you're just looking to relax. A cozy and comfortable restaurant, Malabar's lounge music and open-air bar calm the flustered soul. Choose from a number of Mediterranean and French dishes prepared by world-renowned chefs, whose previous digs include El Bulli, a famous Spanish restaurant.

The Forum nightclub in La Paz is not only the most popular in Bolivia, it's also one of the oldest. Constantly adapting to the changes in style, fashion and music, the club has evolved many times over during the past decades to keep the A-list coming back. Today, lounge music pumps from the loudspeakers for Bolivia's finest young things to enjoy. Forum is the only nightclub in the Bolivian capital that was built to be a nightclub. It's in the upscale Sopocachi neighborhood.

For those looking to dance the night away in Peru, Gotica is the place to be. Right on the beach, this Lima hotspot offers one of best views in the country. It's also inside one of the most popular shopping malls in Peru: Larcomar. DJs from all over the world have spun here. So dance the night way; it's open to 5:00 a.m.